OrangerV1, Main, Exploration, bibRecord, 000756

Carum induced hypothyroidism: an interesting observation and an experiment

Identifieur interne : 000756 ( Main/Exploration ); précédent : 000755; suivant : 000757

Carum induced hypothyroidism: an interesting observation and an experiment

Auteurs : Seyede Maryam Naghibi [Iran] ; Mohamad Ramezani [Iran] ; Narjess Ayati [Iran] ; Seyed Rasoul Zakavi [Iran]

Source :

DARU Journal of Pharmaceutical Sciences [ 1560-8115 ] ; 2015.

RBID : PMC:4310175

Abstract

Carum carvi is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of Carum carvi. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the Carum carvi. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310175

DOI: 10.1186/s40199-015-0094-9
PubMed: 25616491
PubMed Central: 4310175

Affiliations:

Iran

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Carum induced hypothyroidism: an interesting observation and an experiment</title>
<author><name sortKey="Naghibi, Seyede Maryam" sort="Naghibi, Seyede Maryam" uniqKey="Naghibi S" first="Seyede Maryam" last="Naghibi">Seyede Maryam Naghibi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ramezani, Mohamad" sort="Ramezani, Mohamad" uniqKey="Ramezani M" first="Mohamad" last="Ramezani">Mohamad Ramezani</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Pharmaceutical Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Pharmaceutical Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ayati, Narjess" sort="Ayati, Narjess" uniqKey="Ayati N" first="Narjess" last="Ayati">Narjess Ayati</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zakavi, Seyed Rasoul" sort="Zakavi, Seyed Rasoul" uniqKey="Zakavi S" first="Seyed Rasoul" last="Zakavi">Seyed Rasoul Zakavi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25616491</idno>
<idno type="pmc">4310175</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310175</idno>
<idno type="RBID">PMC:4310175</idno>
<idno type="doi">10.1186/s40199-015-0094-9</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000662</idno>
<idno type="wicri:Area/Pmc/Curation">000661</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000583</idno>
<idno type="wicri:Area/Ncbi/Merge">001987</idno>
<idno type="wicri:Area/Ncbi/Curation">001987</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001987</idno>
<idno type="wicri:doubleKey">1560-8115:2015:Naghibi S:carum:induced:hypothyroidism</idno>
<idno type="wicri:Area/Main/Merge">000756</idno>
<idno type="wicri:Area/Main/Curation">000756</idno>
<idno type="wicri:Area/Main/Exploration">000756</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Carum induced hypothyroidism: an interesting observation and an experiment</title>
<author><name sortKey="Naghibi, Seyede Maryam" sort="Naghibi, Seyede Maryam" uniqKey="Naghibi S" first="Seyede Maryam" last="Naghibi">Seyede Maryam Naghibi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ramezani, Mohamad" sort="Ramezani, Mohamad" uniqKey="Ramezani M" first="Mohamad" last="Ramezani">Mohamad Ramezani</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Pharmaceutical Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Pharmaceutical Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ayati, Narjess" sort="Ayati, Narjess" uniqKey="Ayati N" first="Narjess" last="Ayati">Narjess Ayati</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zakavi, Seyed Rasoul" sort="Zakavi, Seyed Rasoul" uniqKey="Zakavi S" first="Seyed Rasoul" last="Zakavi">Seyed Rasoul Zakavi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea>
<wicri:noRegion>Mashhad</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">DARU Journal of Pharmaceutical Sciences</title>
<idno type="ISSN">1560-8115</idno>
<idno type="eISSN">2008-2231</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><italic>Carum carvi</italic>
 is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of <italic>Carum carvi</italic>
. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the <italic>Carum carvi</italic>
. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Khan, M" uniqKey="Khan M">M Khan</name>
</author>
<author><name sortKey="Khan, Au" uniqKey="Khan A">AU Khan</name>
</author>
<author><name sortKey="Najeeb, U R" uniqKey="Najeeb U">u R Najeeb</name>
</author>
<author><name sortKey="Gilani, Ah" uniqKey="Gilani A">AH Gilani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saghir, Mr" uniqKey="Saghir M">MR Saghir</name>
</author>
<author><name sortKey="Sadiq, S" uniqKey="Sadiq S">S Sadiq</name>
</author>
<author><name sortKey="Nayak, S" uniqKey="Nayak S">S Nayak</name>
</author>
<author><name sortKey="Tahir, Mu" uniqKey="Tahir M">MU Tahir</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rezvani, Me" uniqKey="Rezvani M">ME Rezvani</name>
</author>
<author><name sortKey="Roohbakhsh, A" uniqKey="Roohbakhsh A">A Roohbakhsh</name>
</author>
<author><name sortKey="Mosaddegh, Mh" uniqKey="Mosaddegh M">MH Mosaddegh</name>
</author>
<author><name sortKey="Esmailidehaj, M" uniqKey="Esmailidehaj M">M Esmailidehaj</name>
</author>
<author><name sortKey="Khaloobagheri, F" uniqKey="Khaloobagheri F">F Khaloobagheri</name>
</author>
<author><name sortKey="Esmaeili, H" uniqKey="Esmaeili H">H Esmaeili</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sadiq, S" uniqKey="Sadiq S">S Sadiq</name>
</author>
<author><name sortKey="Nagi, Ah" uniqKey="Nagi A">AH Nagi</name>
</author>
<author><name sortKey="Shahzad, M" uniqKey="Shahzad M">M Shahzad</name>
</author>
<author><name sortKey="Zia, A" uniqKey="Zia A">A Zia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hejazian, Ys" uniqKey="Hejazian Y">YS Hejazian</name>
</author>
<author><name sortKey="Dashti, Rm" uniqKey="Dashti R">RM Dashti</name>
</author>
<author><name sortKey="Mahdavi, Sm" uniqKey="Mahdavi S">SM Mahdavi</name>
</author>
<author><name sortKey="Qureshi, Ma" uniqKey="Qureshi M">MA Qureshi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boskabady, Mh" uniqKey="Boskabady M">MH Boskabady</name>
</author>
<author><name sortKey="Alizadeh, M" uniqKey="Alizadeh M">M Alizadeh</name>
</author>
<author><name sortKey="Jahanbin, B" uniqKey="Jahanbin B">B Jahanbin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dashti Rahmatabadi, Mh" uniqKey="Dashti Rahmatabadi M">MH Dashti-Rahmatabadi</name>
</author>
<author><name sortKey="Hejazian, Sh" uniqKey="Hejazian S">SH Hejazian</name>
</author>
<author><name sortKey="Morshedi, A" uniqKey="Morshedi A">A Morshedi</name>
</author>
<author><name sortKey="Rafati, A" uniqKey="Rafati A">A Rafati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lemhadri, A" uniqKey="Lemhadri A">A Lemhadri</name>
</author>
<author><name sortKey="Hajji, L" uniqKey="Hajji L">L Hajji</name>
</author>
<author><name sortKey="Michel, Jb" uniqKey="Michel J">JB Michel</name>
</author>
<author><name sortKey="Eddouks, M" uniqKey="Eddouks M">M Eddouks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilani, Ah" uniqKey="Gilani A">AH Gilani</name>
</author>
<author><name sortKey="Jabeen, Q" uniqKey="Jabeen Q">Q Jabeen</name>
</author>
<author><name sortKey="Ghayur, Mn" uniqKey="Ghayur M">MN Ghayur</name>
</author>
<author><name sortKey="Janbaz, Kh" uniqKey="Janbaz K">KH Janbaz</name>
</author>
<author><name sortKey="Akhtar, Ms" uniqKey="Akhtar M">MS Akhtar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dadkhah, A" uniqKey="Dadkhah A">A Dadkhah</name>
</author>
<author><name sortKey="Fatemi, F" uniqKey="Fatemi F">F Fatemi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tran, L" uniqKey="Tran L">L Tran</name>
</author>
<author><name sortKey="Hammuda, M" uniqKey="Hammuda M">M Hammuda</name>
</author>
<author><name sortKey="Wood, C" uniqKey="Wood C">C Wood</name>
</author>
<author><name sortKey="Xiao, Cw" uniqKey="Xiao C">CW Xiao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parmar, Hs" uniqKey="Parmar H">HS Parmar</name>
</author>
<author><name sortKey="Kar, A" uniqKey="Kar A">A Kar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parmar, Hs" uniqKey="Parmar H">HS Parmar</name>
</author>
<author><name sortKey="Kar, A" uniqKey="Kar A">A Kar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parmar, Hs" uniqKey="Parmar H">HS Parmar</name>
</author>
<author><name sortKey="Kar, A" uniqKey="Kar A">A Kar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name>
</author>
<author><name sortKey="Takayanagi, T" uniqKey="Takayanagi T">T Takayanagi</name>
</author>
<author><name sortKey="Kitajima, J" uniqKey="Kitajima J">J Kitajima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsumura, T" uniqKey="Matsumura T">T Matsumura</name>
</author>
<author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name>
</author>
<author><name sortKey="Kitajima, J" uniqKey="Kitajima J">J Kitajima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takayanagi, T" uniqKey="Takayanagi T">T Takayanagi</name>
</author>
<author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name>
</author>
<author><name sortKey="Kitajima, J" uniqKey="Kitajima J">J Kitajima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belhekar, Mn" uniqKey="Belhekar M">MN Belhekar</name>
</author>
<author><name sortKey="Taur, Sr" uniqKey="Taur S">SR Taur</name>
</author>
<author><name sortKey="Munshi, Rp" uniqKey="Munshi R">RP Munshi</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Iran</li>
</country>
</list>
<tree><country name="Iran"><noRegion><name sortKey="Naghibi, Seyede Maryam" sort="Naghibi, Seyede Maryam" uniqKey="Naghibi S" first="Seyede Maryam" last="Naghibi">Seyede Maryam Naghibi</name>
</noRegion>
<name sortKey="Ayati, Narjess" sort="Ayati, Narjess" uniqKey="Ayati N" first="Narjess" last="Ayati">Narjess Ayati</name>
<name sortKey="Ramezani, Mohamad" sort="Ramezani, Mohamad" uniqKey="Ramezani M" first="Mohamad" last="Ramezani">Mohamad Ramezani</name>
<name sortKey="Zakavi, Seyed Rasoul" sort="Zakavi, Seyed Rasoul" uniqKey="Zakavi S" first="Seyed Rasoul" last="Zakavi">Seyed Rasoul Zakavi</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000756 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000756 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Bois
   |area=    OrangerV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4310175
   |texte=   Carum induced hypothyroidism: an interesting observation and an experiment
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25616491" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a OrangerV1

This area was generated with Dilib version V0.6.25.
Data generation: Sat Dec 3 17:11:04 2016. Site generation: Wed Mar 6 18:18:32 2024

Serveur d'exploration sur l'oranger

Carum induced hypothyroidism: an interesting observation and an experiment

Carum induced hypothyroidism: an interesting observation and an experiment

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur l'oranger
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.